標題: Mammalian Ste20-like protein kinase 3 mediates trophoblast apoptosis in spontaneous delivery
作者: Wu, Hung-Yi
Lin, Chia-Ying
Lin, Tze-Yi
Chen, Tai-Chang
Yuan, Chiun-Jye
生物科技學系
Department of Biological Science and Technology
關鍵字: Mst3;oxidative stress;placenta;trophoblasts;apoptosis;parturition
公開日期: 1-Feb-2008
摘要: The placenta is essential in transferring gases and nutrients from the mother to the developing fetus. Trophoblast apoptosis may cause labor or other pregnancy-related disorders. This study demonstrated the essential role of Mst3, a human Ste20-like protein kinase, in the oxidative stress-induced apoptosis of trophoblasts of term placenta in normal spontaneous delivery. Oxidative stress, but not hormones released during labor such as prostaglandin E-1, oxytocin or angiotensin II, induces the expression of Mst3 and apoptosis of human term placenta after elective Cesarean section without labor pain. The role of Mst3 in oxidative stress-induced apoptosis was further demonstrated in the 3A-sub-E, a human trophoblast cell line. The H2O2-induced apoptosis of 3A-sub-E cells was largely suppressed by overexpressed Mst3(KR), the kinase-dead mutant or by selective knockdown of endogenous Mst3. Further studies showed that Jun N-terminal kinase (JNK) may participate in the signaling pathway of H2O2-induced apoptosis by mediating the level of Mst3. Subsequently, caspase 3 and other downstream apoptotic components may be activated by Mst3 and trigger the apoptotic process in human trophoblasts.
URI: http://dx.doi.org/10.1007/s10495-007-0161-x
http://hdl.handle.net/11536/9735
ISSN: 1360-8185
DOI: 10.1007/s10495-007-0161-x
期刊: APOPTOSIS
Volume: 13
Issue: 2
起始頁: 283
結束頁: 294
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