標題: Camellia sinensis tea melanin suppresses transformation of the aryl hydrocarbon receptor and prevents against dioxin-induced toxicity in mice
作者: Hung, Yao-Ching
Huang, Guewha Steven
Sava, Vasyl M.
Makan, Svetlana Y.
Hong, Meng-Yen
材料科學與工程學系奈米科技碩博班
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
關鍵字: aryl hydrocarbon receptor;Camellia sinensis tea;CYP1A1;melanin;2,3,7,8-tetrachlorodibenzo-p-dioxin
公開日期: 1-Feb-2008
摘要: The suppressive effects of Camellia sinensis tea melanin (CSTM) on transformation of aryl hydrocarbon receptor (AhR) induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were disclosed for the first time. CSTM strongly inhibited TCDD-induced toxicity with IC50 equalling 20.4 mu g mL(-1). Daily administration of CSTM (40 mg kg(-1), p.o.) prevented TCDD-induced body weight loss, ameliorated TCDD-induced mortality and prevented TCDD-induced hepatomegaly and thymic atrophy. Co-administration of CSTM significantly inhibited TCDD-induced hepatic CYP1 A1 activity. CSTM retarded transformation of AhR in vitro. In animals treated with CSTM, the antibody-secreting cells produced significantly (P < 0.05) more antibodies (32-34%) than the antigen control. Administration of TCDD caused a suppression of antibody-forming cells of 29-33% against the antigen control level. Co-administration of CSTM restored immunity to the control level. We demonstrated that CSTM directly competed with TCDD during the transformation of AhR and suppressed the downstream activation of genes associated with TCDD toxicity.
URI: http://dx.doi.org/10.1111/j.1365-2621.2006.01428.x
http://hdl.handle.net/11536/9705
ISSN: 0950-5423
DOI: 10.1111/j.1365-2621.2006.01428.x
期刊: INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
Volume: 43
Issue: 2
起始頁: 261
結束頁: 269
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