標題: Parallel synthesis of 2-sulphanylated bis-benzimidazoles on soluble polymer support
作者: Chang, Chia-Mao
Kulkarni, Manohar V.
Chen, Chih-Hau
Wang, Chi-Hsiang
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 1-May-2008
摘要: A well-sustained multistep synthetic protocol has been designed for the PEG-functionalized aromatic acid amide to generate a molecular library of 2-alkylthio bis-benzimidazoles. An attempted synthesis of benzimidazole-2-thiol in dichloromethane has led to S-chloromethyl methyl sulfides, mimicking bacterial enzymatic systems. Regioselective S-alkylation was brought about under controlled conditions using a mild base at room temperature. The polymer-free compounds, 2-sulfanylated bisbenzimidazoles, were obtained in high yields and high purities. Chemical shift changes in proton and carbon NMR-have been employed to monitor the progress of the reaction steps and to prove the site of S-alkylation, respectively.
URI: http://dx.doi.org/10.1021/cc7002045
http://hdl.handle.net/11536/9421
ISSN: 1520-4766
DOI: 10.1021/cc7002045
期刊: JOURNAL OF COMBINATORIAL CHEMISTRY
Volume: 10
Issue: 3
起始頁: 466
結束頁: 474
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