標題: Synthesis and self-assembly of helical polypeptide-random coil amphiphilic diblock copolymer
作者: Kuo, Shiao-Wei
Lee, Hsin-Fang
Huang, Chih-Feng
Huang, Cheng-Jynn
Chang, Feng-Chih
應用化學系
Department of Applied Chemistry
關鍵字: block copolymer;hydrogen bonding;polypeptide;self-assembly;self-organization
公開日期: 1-May-2008
摘要: Three amphiphilic rod-coil diblock copolymers, poly(2-ethyl-2-oxazoline-b-/-benzyl-L-glutamate) (PEOz-b-PBLG),G), incorporating the same-length PEOz block length and various lengths of their PBLG blocks, were synthesized through a combining of living cationic and N-carboxyanhydride (NCA) ring-opening polymerizations. In the bulk, these block copolymers display thermotropic liquid crystalline behavior. The self-assembled aggregates that formed from these diblock copolymers in aqueous solution exhibited morphologies that differed from those obtained in alpha-helicogenic solvents, that is, solvents in which the PBLG blocks adopt rigid alpha-helix conformations. In aqueous solution, the block copolymers self-assembled into spherical micelles and vesicular aggregates because of their amphiphilic structures. In helicogenic solvents (in this case, toluene and benzyl alcohol), the PEOz-b-PBLG copolymers exhibited rod-coil chain properties, which result in a diverse array of aggregate morphologies (spheres, vesicles, ribbons, and tube nanostructures) and thermoreversible gelation behavior. (C) 2008 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/pola.22632
http://hdl.handle.net/11536/9381
ISSN: 0887-624X
DOI: 10.1002/pola.22632
期刊: JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume: 46
Issue: 9
起始頁: 3108
結束頁: 3119
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