標題: Regulatory mechanisms of atrial fibrotic remodeling in atrial fibrillation
作者: Lin, C. -S.
Pan, C. -H.
生物科技學系
Department of Biological Science and Technology
關鍵字: angiotensin II;atrial fibrillation;atrial remodeling;inflammation;matrix metalloproteinases;oxidative stress;tissue inhibitors of matrix metalloproteinases;transforming growth factor-beta 1
公開日期: 1-May-2008
摘要: Electrical, contractile and structural remodeling have been characterized in atrial fibrillation (AF), and the latter is considered to be the major contributor to AF persistence. Recent data show that interstitial fibrosis can predispose to atrial conduction impairment and AF induction. The interplay between cardiac matrix metalloproteinases (MMPs) and their endogenous inhibitors, tissue inhibitors of MMPs (TIMPs), is thought to be critical in atrial extracellular matrix (ECM) metabolism. At the molecular level, angiotensin II, transforming growth factor-beta 1, inflammation and oxidative stress are particularly important for ECM dysregulation and atrial fibrotic remodeling in AF. Therefore, we review recent advances in the understanding of the atrial fibrotic process, the major downstream components in this remodeling process, and the expression and regulation of MMPs and TIMPs. We also describe the activation of bioactive molecules in both clinical studies and animal models to modulate MMPs and TIMPs and their effects on atrial fibrosis in AF.
URI: http://dx.doi.org/10.1007/s00018-008-7408-8
http://hdl.handle.net/11536/9369
ISSN: 1420-682X
DOI: 10.1007/s00018-008-7408-8
期刊: CELLULAR AND MOLECULAR LIFE SCIENCES
Volume: 65
Issue: 10
起始頁: 1489
結束頁: 1508
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