Title: Susceptibilities to amphotericin B and fluconazole of Candida species in Taiwan Surveillance of Antimicrobial Resistance of Yeasts 2006
Authors: Yang, Yun-Liang
Wang, An-Huei
Wang, Chih-Wei
Cheng, Wei-Ting
Li, Shu-Ying
Lo, Hsiu-Jung
生物科技學系
Department of Biological Science and Technology
Keywords: Candida;susceptibility;resistance
Issue Date: 1-Jun-2008
Abstract: Susceptibilities to amphotericin B and fluconazole of 964 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2006 were determined. There were 419 (43.5%) Candida albicans, 246 (25.5%) Candida tropicalis, 211 (21.9%) Candida glabrata, 62 (6.4%) Candida parapsilosis, 14 (1.5%) Candida krusei, and 12 (1.2%) others. Interestingly, 16 of the 17 amphotericin B-resistant isolates were non-albicans Candida species. The resistant rate to amphotericin B has decreased from 2.5% in 2002 to 1.8% in 2006. On the other hand, there were 132 C. tropicalis, 14 C. krusei, 10 C. albicans, and 9 C. glabrata isolates that had MICs to fluconazole >= 64 mu g/mL. The prevalence of isolates with such high MICs was significantly higher than that in 2002 (17.1% versus 1.9%). Our results further indicate that most of the isolates with MICs to fluconazole >= 64 mu g/mL exhibited the "trailing" phenomenon. (C) 2008 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.diagmicrobio.2008.01.011
http://hdl.handle.net/11536/8749
ISSN: 0732-8893
DOI: 10.1016/j.diagmicrobio.2008.01.011
Journal: DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume: 61
Issue: 2
Begin Page: 175
End Page: 180
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