標題: Surface-assisted laser desorption/ionization mass spectrometry on titania nanotube arrays
作者: Lo, Chun-Yuan
Lin, Jia-Yi
Chen, Wei-Yu
Chen, Cheng-Tai
Chen, Yu-Chie
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
公開日期: 1-Jul-2008
摘要: Titania nanotube arrays (NTA) generated from anodizing processes are tested as the substrate for surface-assisted laser desorption/ionization mass spectrometry (SALDI MS). The background generated from fitania NTA is very low, making the approach suitable for the analysis of small molecules. The upper detectable mass is similar to 29 kDa. Homogeneous sample deposition leads to good shot-to-shot reproducibility and suitability for quantitative analysis. Additionally, phosphopeptides can be selectively trapped on the fitania NTA substrate, as illustrated by simply depositing a tryptic digest of beta-casein followed by titania NTA SALDI MS analysis. The detection limit for small organics and peptides is in low fmol.
URI: http://dx.doi.org/10.1016/j.jasms.2008.04.025
http://hdl.handle.net/11536/8666
ISSN: 1044-0305
DOI: 10.1016/j.jasms.2008.04.025
期刊: JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
Volume: 19
Issue: 7
起始頁: 1014
結束頁: 1020
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