標題: Blosignaling of mammalian Ste20-related kinases
作者: Ling, Pin
Lu, Te-Jung
Yuan, Chiun-Jye
Lai, Ming-Derg
生物科技學系
Department of Biological Science and Technology
關鍵字: ste20;kinase;signal pathway;MST;apoptosis contents
公開日期: 1-Jul-2008
摘要: Sterile 20 (ste20) protein is an upstream ser/thr kinase in yeast, and several mammalian Ste20-like (MST) kinases have been identified. This review focuses on the signal transduction, interacting proteins, and potential biological function of MST1, 2, 3, and 4 kinases, since several novel signal pathways of these kinases have been characterized recently. MST1 and MST2 kinases play an important role in cell growth and apoptosis, and the signal pathways involves many important molecules including RAS, AKT, and FOXO3. MST3 and MST4 have similar kinase domain, but have opposite effects on apoptosis and transformation. The downstream signaling molecules of these two kinases are beginning to be elucidated. Based on the expression pattern and signal pathways, we will discuss the perspective biological functions of four MST family kinases in cancer, immune, cardiovascular, and brain function. (c) 2007 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.cellsig.2007.12.019
http://hdl.handle.net/11536/8660
ISSN: 0898-6568
DOI: 10.1016/j.cellsig.2007.12.019
期刊: CELLULAR SIGNALLING
Volume: 20
Issue: 7
起始頁: 1237
結束頁: 1247
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