標題: OGtree: a tool for creating genome trees of prokaryotes based on overlapping genes
作者: Jiang, Li-Wei
Lin, Kuang-Lun
Lu, Chin Lung
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-Jul-2008
摘要: OGtree is a web-based tool for constructing genome trees of prokaryotic species based on a measure of combining overlapping-gene content and overlapping-gene order in their whole genomes. The overlapping genes (OGs) are defined as adjacent genes whose coding sequences overlap partially or entirely. In fact, OGs are ubiquitous in microbial genomes and more conserved between species than non-OGs. Based on these properties, it has been suggested that OGs can serve as better phylogenetic characters than non-OGs for reconstructing the evolutionary relationships among microbial genomes. OGtree takes the accession numbers of prokaryotic genomes as its input. It then downloads their complete genomes from the National Centre for Biotechnology Information and identifies OGs in each genome and their orthologous OGs in other genomes. Next, OGtree computes an overlapping-gene distance between each pair of input genomes based on a combination of their OG content and orthologous OG order. Finally, it utilizes distance-based methods of building tree to reconstruct the genome trees of input prokaryotic genomes according to their pairwise OG distance. OGtree is available online at http://bioalgorithm.life.nctu.edu.tw/OGtree/.
URI: http://dx.doi.org/10.1093/nar/gkn240
http://hdl.handle.net/11536/8628
ISSN: 0305-1048
DOI: 10.1093/nar/gkn240
期刊: NUCLEIC ACIDS RESEARCH
Volume: 36
Issue: 
起始頁: W475
結束頁: W480
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