Title: 5-phenylpyridazinones - A serendipitous route from coumarins
Authors: Ghate, Manjunath D.
Jadhav, Vithal B.
Shastri, Lokesh A.
Kulkarni, Manohar V.
Kulkarni, Geetha M.
Chen, Chih-Hau
Sun, Chung-Ming
Department of Applied Chemistry
Issue Date: 7-Jul-2008
Abstract: A new route of the ring transformation has been discovered during the reaction of 4-bromomethylcoumarins with hydrazine hydrate leading to the formation of pharmacologically important pyridazinones in a single step with very high yields. These so obtained pyridazinones have the potential for further functional group interconversions. (C) 2008 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2008.05.015
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2008.05.015
Volume: 49
Issue: 28
Begin Page: 4394
End Page: 4396
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