標題: Synthesis and characterization of nanoporous SiO2/pHEMA biocomposites
作者: Liu, Yen-Yu
Liu, Tse-Ying
Chen, San-Yuan
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 1-Aug-2008
摘要: Porous SiO2/pHEMA biocomposites were synthesized in situ by incorporating silica nanoparticles with a hydroxyethyl methacrylate (HEMA) monomer, following a UV-induced photopolymerization. The nanostructure of the composites was characterized and the resulting physical properties were examined. The release kinetics of the model molecule-vitamin B12-and the hemocompatibility of the porous SiO2/pHEMA composites were investigated. Heterogeneous reaction kinetics is proposed to be the formation mechanism of the nanoporosity in the pHEMA matrix as a result of incorporating silica nanoparticles following photopolymerization. Experimental results also demonstrated that the incorporation of the silica nanoparticles into the pHEMA matrix not only enhanced the mechanical property but also maintained a good hemocompatibility of the resulting biocomposites. In addition, it was observed that the drug release profile of the composites (in the form of a membrane) can be precisely regulated from a two-stage pattern to one-stage pattern by varying the concentration of both the SiO2 nanoparticles and HEMA monomer during synthesis. The permeability of the model drug was enhanced by two orders of magnitude from 4.22 x10(-7) cm(2)/h to 3.92 x 10(-5) cm(2)/h by controlling the micro-to-nanostructure of the composites. The platelet adhesion experiment demonstrated low aggregation of the platelets on the surface of the biocomposite membranes, indicating a promising antithrombotic property.
URI: http://dx.doi.org/10.1007/s10856-007-3355-4
http://hdl.handle.net/11536/8526
ISSN: 0957-4530
DOI: 10.1007/s10856-007-3355-4
期刊: JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
Volume: 19
Issue: 8
起始頁: 2903
結束頁: 2911
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