|Title:||Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins|
|Authors:||Kalkhambkar, Rajesh G.|
Kulkarni, Geeta M.
Kamanavalli, Chandrappa M.
Asdaq, S. M. B.
Sun, Chung Ming
Department of Applied Chemistry
|Keywords:||Fluorinated coumarin;Fluorinated 1-aza coumarin;Anti-bacterial;Anti-fungal;Analgesic;Anti-inflammatory|
|Abstract:||A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, (1)H NMR, (13)C NMR, (19)F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. (C) 2007 Elsevier Masson SAS. All rights reserved.|
|Journal:||EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY|
|Appears in Collections:||Articles|
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