Title: Synthesis and biological activities of some new fluorinated coumarins and 1-aza coumarins
Authors: Kalkhambkar, Rajesh G.
Kulkarni, Geeta M.
Kamanavalli, Chandrappa M.
Premkumar, N.
Asdaq, S. M. B.
Sun, Chung Ming
Department of Applied Chemistry
Keywords: Fluorinated coumarin;Fluorinated 1-aza coumarin;Anti-bacterial;Anti-fungal;Analgesic;Anti-inflammatory
Issue Date: 1-Oct-2008
Abstract: A series of new fluorinated coumarins and 1-aza coumarins have been synthesized and the presence of fluorine in these molecules and its effect on their anti-microbial, anti-inflammatory and analgesic activities are discussed. The results of bioassay showed that these newly synthesized compounds containing fluorine exhibit moderate analgesic and excellent anti-inflammatory and potential anti-bacterial and anti-fungal activities, compared to the other halogenated compounds. All the newly synthesized compounds were characterized by elemental analysis, IR, (1)H NMR, (13)C NMR, (19)F NMR, EI-MS, and FAB-MS. The ORTEP diagram of one of the compounds is reported herein. (C) 2007 Elsevier Masson SAS. All rights reserved.
URI: http://dx.doi.org/10.1016/j.ejmech.2007.08.007
ISSN: 0223-5234
DOI: 10.1016/j.ejmech.2007.08.007
Volume: 43
Issue: 10
Begin Page: 2178
End Page: 2188
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