標題: Integrated multiple multi-photon imaging and Raman spectroscopy for characterizing structure-constituent correlation of tissues
作者: Jhan, Jhen-Wei
Chang, Wei-Tien
Chen, Hung-Che
Lee, Yu-Tsung
Wu, Ming-Fang
Chen, Chung-Hsuan
Liau, Ian
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
公開日期: 13-Oct-2008
摘要: Histopathological imaging of tissues often requires extensive sample preparation including fixation and staining in order to highlight characteristic alterations associated with diseases. Herein, we report an integrated spectro-microscopy approach based on a combination of multimodal multi-photon imaging and Raman micro-spectroscopy and demonstrate label-free characterization of the structure-constituent correlation of porcine skin. The multi-modal imaging allows the visualization of dermatological features whereas Raman micro-spectroscopy enables the identification of their 'molecular fingerprints'. By obtaining both structural and molecular-level information of tissue constituents, this integrated approach can offer new insight into the patho-physiological status of tissues. (c) 2008 Optical Society of America
URI: http://dx.doi.org/10.1364/OE.16.016431
http://hdl.handle.net/11536/8253
ISSN: 1094-4087
DOI: 10.1364/OE.16.016431
期刊: OPTICS EXPRESS
Volume: 16
Issue: 21
起始頁: 16431
結束頁: 16441
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