標題: Identifying Discriminative Amino Acids Within the Hemagglutinin of Human Influenza A H5N1 Virus Using a Decision Tree
作者: Wu, Li-Ching
Horng, Jorng-Tzong
Huang, Hsien-Da
Chen, Wei-Long
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: Decision tree;hemagglutinin (HA);influenza A H5N1 virus
公開日期: 1-Nov-2008
摘要: Recently, the H5N1 virus has had an increasingly important impact on human life. This is because more and more people are becoming infected with this virus, and the possibility of a serious pandemic with human to human transmission is looming. This might occur if the genome of this influenza virus mutates either by antigenic drift or by antigenic shift, especially if there is a mutation of the hemagglutinin (HA) glycoprotein. The HA is the surface glycoprotein, and it binds to sialic acid of the host cell surface receptor. Thus, the combination of HA and sialic acid are central to whether influenza virus infects humans. In this study, we selected 497 HA protein sequences from the National Center for Biotechnology Information (NCBI) Influenza Resource database, and used a decision tree method to identify discriminative amino acids in the HA protein sequences that may possibly influence the binding of HA to sialic acid. Four such amino acid positions at 54, 55, 241, and 281 were identified and these may play an important role in infection by H5N1 influenza virus.
URI: http://dx.doi.org/10.1109/TITB.2008.896871
http://hdl.handle.net/11536/8210
ISSN: 1089-7771
DOI: 10.1109/TITB.2008.896871
期刊: IEEE TRANSACTIONS ON INFORMATION TECHNOLOGY IN BIOMEDICINE
Volume: 12
Issue: 6
起始頁: 689
結束頁: 695
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