標題: Importance of Saccharomyces cerevisiae Oxidosqualene-Lanosterol Cyclase Tyrosine 707 Residue for Chair-Boat Bicyclic Ring Formation and Deprotonation Reactions
作者: Wu, Tung-Kung
Wang, Tsai-Ting
Chang, Cheng-Hsiang
Liu, Yuan-Ting
Shie, Wen-Shiang
生物科技學系
Department of Biological Science and Technology
公開日期: 6-Nov-2008
摘要: A contact mapping strategy was applied to identity putative amino acid residues that influence the oxidosqualene-lanosterol B-ring cyclization reaction. A bicyclic intermediate with two altered deprotonation products, in conjunction with lanosterol, were isolated from the ERG7(Y707X) mutants, indicating that the Tyr707 residue may play a functional role in stabilizing the chair-boat bicyclic C-8 cation and the lanosteryl C-8/C-9 cation intermediates.
URI: http://dx.doi.org/10.1021/ol802036c
http://hdl.handle.net/11536/8159
ISSN: 1523-7060
DOI: 10.1021/ol802036c
期刊: ORGANIC LETTERS
Volume: 10
Issue: 21
起始頁: 4959
結束頁: 4962
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