Title: Detection of gold nanoparticles using an immunoglobulin-coated piezoelectric sensor
Authors: Chen, Yu-Shiun
Hung, Yao-Ching
Chen, Kaochao
Huang, Guewha Steven
Department of Materials Science and Engineering
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
Issue Date: 10-Dec-2008
Abstract: Since the existence of nanoparticles in our environment has already attracted considerable attention due to their possible toxic impact on biological systems, the field detection of nanoparticles is becoming a technology that will be much in need. We have constructed a piezoelectric sensor with an antibody-coated electrode. The antiserum can bind gold nanoparticles with a high degree of selectivity and sensitivity. The biosensor thus constructed can detect 4, 5, or 6 nm gold nanoparticles (GNPs) depending on the coated antiserum. The sensitivity for the detection of 5 nm GNPs was 10.3 +/- 0.9 ng Hz(-1), with the low limit of detection at 5.5 ng. A quartz crystal microbalance (QCM) sensor was capable of detecting GNPs and other types of nanoparticle, such as ZnO, or Fe(3)O(4). The current study provides, for the first time, a platform for detecting nanoparticles in a convenient, economical manner.
URI: http://dx.doi.org/10.1088/0957-4484/19/49/495502
ISSN: 0957-4484
DOI: 10.1088/0957-4484/19/49/495502
Volume: 19
Issue: 49
End Page: 
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