標題: sRNAMap: genomic maps for small non-coding RNAs, their regulators and their targets in microbial genomes
作者: Huang, Hsi-Yuan
Chang, Heng-Yi
Chou, Chih-Hung
Tseng, Ching-Ping
Ho, Shinn-Ying
Yang, Chi-Dung
Ju, Yih-Wei
Huang, Hsien-Da
生物科技學系
生物資訊及系統生物研究所
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
公開日期: 1-一月-2009
摘要: Small non-coding RNAs (sRNAs) carry out a variety of biological functions and affect protein synthesis and protein activities in prokaryotes. Recently, numerous sRNAs and their targets were identified in Escherichia coli and in other bacteria. It is crucial to have a comprehensive resource concerning the annotation of small non-coding RNAs in microbial genomes. This work presents an integrated database, namely sRNAMap, to collect the sRNA genes, the transcriptional regulators of sRNAs and the sRNA target genes by integrating a variety of biological databases and by surveying literature. In this resource, we collected 397 sRNAs, 62 regulators/sRNAs and 60 sRNAs/targets in 70 microbial genomes. Additionally, more valuable information of the sRNAs, such as the secondary structure of sRNAs, the expressed conditions of sRNAs, the expression profiles of sRNAs, the transcriptional start sites of sRNAs and the cross-links to other biological databases, are provided for further investigation. Besides, various textual and graphical interfaces were designed and implemented to facilitate the data access in sRNAMap. sRNAMap is available at http://sRNAMap.mbc.nctu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkn852
http://hdl.handle.net/11536/7820
ISSN: 0305-1048
DOI: 10.1093/nar/gkn852
期刊: NUCLEIC ACIDS RESEARCH
Volume: 37
Issue: 
起始頁: D150
結束頁: D154
顯示於類別:期刊論文


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  1. 000261906200027.pdf