標題: A High-Sensitivity CMOS-Compatible Biosensing System Based on Absorption Photometry
作者: Chang, Yu-Wei
Yu, Ping-Chun
Huang, Yang-Tung
Yang, Yuh-Shyong
生物科技學系
電子工程學系及電子研究所
Department of Biological Science and Technology
Department of Electronics Engineering and Institute of Electronics
關鍵字: Biomedical transducers;CMOS analog integrated circuits;medical diagnosis;optical receivers
公開日期: 1-Jan-2009
摘要: An optical biosensing system based on a standard CMOS technology and absorption photometry is proposed. Within the compact prototype, a CMOS sensor consisting a P(+)/N(well) finger photodiode and a transimpedance amplifier was implemented in a standard 0.35-mu m CMOS technology. The ABTS/H(2)O(2)/HRP method was adopted to be coupled with various analytes of interest, such as glucose and histamine, which can serve as the basis for medical diagnosis. The experimental results demonstrate that the minimum concentrations successfully detected for H(2)O(2), glucose, and histamine are 1 mu M, 1 mu M, and 10 mu M, respectively. The detection limits are at least one order of magnitude better than those of reported CMOS biosensors, and are even comparable to those of a commercial spectrophotometer.
URI: http://dx.doi.org/10.1109/JSEN.2008.2011079
http://hdl.handle.net/11536/7764
ISSN: 1530-437X
DOI: 10.1109/JSEN.2008.2011079
期刊: IEEE SENSORS JOURNAL
Volume: 9
Issue: 1-2
起始頁: 120
結束頁: 127
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