標題: Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer
作者: Wu, Yao-Kuang
Chen, Kuei-Tien
Kuo, Yung-Bin
Huang, Ya-Shu
Chan, Err-Cheng
生物科技學系
Department of Biological Science and Technology
關鍵字: Survivin expression;Pleural effusion;Survival rate;Prognosis;Lung cancer
公開日期: 18-一月-2009
摘要: in the present study, pleural effusions are the first time to be used as the specimens for detection of survivin expression in lung cancer patients. We demonstrated that by quantifying survivin expression with enzyme-linked immunosorbent assay (ELISA) in the 80 effusion samples exhibited a diagnostic power of 85% and 75% in sensitivity and specificity, respectively. A multivariate analysis with the Cox regression model revealed that both high survivin expression and cancer cells of stage IV were the indicators for poor prognosis of lung cancer. In conclusion, quantitative assay of survivin in pleural effusion could be useful both in diagnosis and prognosis for lung cancer. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.canlet.2008.08.023
http://hdl.handle.net/11536/7738
ISSN: 0304-3835
DOI: 10.1016/j.canlet.2008.08.023
期刊: CANCER LETTERS
Volume: 273
Issue: 2
起始頁: 331
結束頁: 335
顯示於類別:期刊論文


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