標題: Antioxidative and hepatoprotective effects of magnolol on acetaminophen-induced liver damage in rats
作者: Chen, Yung-Hsiang
Lin, Feng-Yen
Liu, Po-Len
Huang, Yi-Tsau
Chiu, Jen-Hwey
Chang, Yi-Chun
Man, Kee-Ming
Hong, Chuang-Ye
Ho, Yen-Yi
Lai, Ming-Tsung
交大名義發表
National Chiao Tung University
關鍵字: Magnolol;Antioxidant;Acetaminophen;Hepatotoxicity;Lipid peroxidation
公開日期: 1-二月-2009
摘要: Acute liver failure (ALF), an often fatal condition characterized by massive hepatocyte necrosis, is frequently caused by drug poisoning, particularly with acetaminophen (N-acetyl-p-aminophenol/APAP). Hepatocyte necrosis is consecutive to glutathione (GSH) depletion and mitochondrial damage caused by reactive oxygen species (ROS) overproduction. Magnolol, one major phenolic constituent of Magnolia officinalis, have been known to exhibit potent antioxidative activity. In this study, the anti-hepatotoxic activity of magnolol on APAP-induced toxicity in the Sprague-Dawley rat liver was examined. After evaluating the changes of several biochemical parameters in serum, the levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactate dehydrogenase (LDH) were elevated by APAP (500 mg/kg) intraperitoneal administration (8 and 24 h) and reduced by treatment with magnolol (0.5 h after APAP administration; 0.01, 0.1, and 1 mu g/kg). Histological changes around the hepatic central vein, lipid peroxidation (thiobarbituric acid-reactive substance/TBARS), and GSH depletion in liver tissue induced by APAP were also recovered by magnolol treatment. The data show that oxidative stress followed by lipid peroxidation may play a very important role in the pathogenesis of APAP-induced hepatic injury; treatment with lipid-soluble antioxidant, magnolol, exerts anti-hepatotoxic activity. Our study points out the potential interest of magnolol in the treatment of toxic ALF.
URI: http://dx.doi.org/10.1007/s12272-009-1139-8
http://hdl.handle.net/11536/7675
ISSN: 0253-6269
DOI: 10.1007/s12272-009-1139-8
期刊: ARCHIVES OF PHARMACAL RESEARCH
Volume: 32
Issue: 2
起始頁: 221
結束頁: 228
顯示於類別:期刊論文


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