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dc.contributor.authorHung, Hui-Chenen_US
dc.contributor.authorTseng, Ching-Pingen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.contributor.authorJu, Yi-Weien_US
dc.contributor.authorTseng, Sung-Nainen_US
dc.contributor.authorChen, Yen-Fuen_US
dc.contributor.authorChao, Yu-Shengen_US
dc.contributor.authorHsieh, Hsing-Pangen_US
dc.contributor.authorShih, Shin-Ruen_US
dc.contributor.authorHsu, John T. -A.en_US
dc.date.accessioned2014-12-08T15:10:01Z-
dc.date.available2014-12-08T15:10:01Z-
dc.date.issued2009-02-01en_US
dc.identifier.issn0166-3542en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.antiviral.2008.10.006en_US
dc.identifier.urihttp://hdl.handle.net/11536/7652-
dc.description.abstractThere is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA). We found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC(50)S (effective concentration to inhibit NA activity by 50%) values at low micromolar concentrations. ATA was equally potent in inhibiting the NA activity derived from wild-type NA and its H274Y mutant which renders NA resistance to inhibition by oseltamivir. Although ATA is structurally distinct from sialic acid, molecular modeling experiments suggested that ATA binds to NA at the enzyme's substrate binding site. These results indicate that ATA may be a good starting material for the design of a novel class of NA inhibitors for the treatment influenza viruses. (C) 2008 Elsevier B.V. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectAurintricarboxylic aciden_US
dc.subjectInfluenzaen_US
dc.subjectNeuraminidaseen_US
dc.subjectAntiviralsen_US
dc.titleAurintricarboxylic acid inhibits influenza virus neuraminidaseen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.antiviral.2008.10.006en_US
dc.identifier.journalANTIVIRAL RESEARCHen_US
dc.citation.volume81en_US
dc.citation.issue2en_US
dc.citation.spage123en_US
dc.citation.epage131en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000263189800004-
dc.citation.woscount52-
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