標題: Aurintricarboxylic acid inhibits influenza virus neuraminidase
作者: Hung, Hui-Chen
Tseng, Ching-Ping
Yang, Jinn-Moon
Ju, Yi-Wei
Tseng, Sung-Nain
Chen, Yen-Fu
Chao, Yu-Sheng
Hsieh, Hsing-Pang
Shih, Shin-Ru
Hsu, John T. -A.
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
關鍵字: Aurintricarboxylic acid;Influenza;Neuraminidase;Antivirals
公開日期: 1-二月-2009
摘要: There is a continuing threat that the highly pathogenic avian influenza virus will cause future influenza pandemics. In this study, we screened a library of compounds that are biologically active and structurally diverse for inhibitory activity against influenza neuraminidase (NA). We found that aurintricarboxylic acid (ATA) is a potent inhibitor of NA activity of both group-1 and group-2 influenza viruses with IC(50)S (effective concentration to inhibit NA activity by 50%) values at low micromolar concentrations. ATA was equally potent in inhibiting the NA activity derived from wild-type NA and its H274Y mutant which renders NA resistance to inhibition by oseltamivir. Although ATA is structurally distinct from sialic acid, molecular modeling experiments suggested that ATA binds to NA at the enzyme's substrate binding site. These results indicate that ATA may be a good starting material for the design of a novel class of NA inhibitors for the treatment influenza viruses. (C) 2008 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.antiviral.2008.10.006
http://hdl.handle.net/11536/7652
ISSN: 0166-3542
DOI: 10.1016/j.antiviral.2008.10.006
期刊: ANTIVIRAL RESEARCH
Volume: 81
Issue: 2
起始頁: 123
結束頁: 131
顯示於類別:期刊論文


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