標題: Enantioselective Synthesis of Benzimidazolyl Quinoxalinones on Soluble Polymer Support Using Focused Microwave Irradiation
作者: Chanda, Kaushik
Kuo, Jaren
Chen, Chih-Hau
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 1-Mar-2009
摘要: Focused microwave irradiation has been applied to a multistep synthetic sequence of reactions designed to generate benzimidazolyl quinoxalinones using a soluble polymer support. They were obtained by the ipso-fluoro (S(N)Ar) displacement of the immobilized ortho-nitro fluoro benzimidazoles with chiral alpha amino esters under microwave irradiation. Intermediate chiral organic-polymer conjugates when subjected to neutral reduction underwent a spontaneous intramolecular ring closure. Cleavage of the polymer support, at room temperature, did not cause any significant racemization resulting in the generation of a chiral molecular library with two points of structural diversity.
URI: http://dx.doi.org/10.1021/cc800137p
http://hdl.handle.net/11536/7582
ISSN: 1520-4766
DOI: 10.1021/cc800137p
期刊: JOURNAL OF COMBINATORIAL CHEMISTRY
Volume: 11
Issue: 2
起始頁: 252
結束頁: 260
Appears in Collections:Articles


Files in This Item:

  1. 000264110800012.pdf