標題: Non-lethal Candida albicans cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by lethal wild-type cells
作者: Yang, Yun-Liang
Wang, Chih-Wei
Chen, Chiung-Tony
Wang, Min-Hsien
Hsiao, Chin-Fu
Lo, Hsiu Juny
生物科技學系
Department of Biological Science and Technology
關鍵字: Candida albicans;Mouse model;Protection;Virulence
公開日期: 1-Mar-2009
摘要: Although Candida albicans cph1/cph1 efg1/efg1 mutant cells are not lethal to mice, they proliferated in infected mice instead of simply being cleared by the host immune system. Here, we have shown that the cph1/cph1 efg1/efg1 mutant partially protects mice from systemic infections by the lethal wild-type Candida albicans cells. Our results further indicate that a second dose of the cph1/cph1 efg1/efg1 mutant did not boost the degree of protection. (c) 2008 The British Mycological Society. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.mycres.2008.11.016
http://hdl.handle.net/11536/7580
ISSN: 0953-7562
DOI: 10.1016/j.mycres.2008.11.016
期刊: MYCOLOGICAL RESEARCH
Volume: 113
Issue: 
起始頁: 388
結束頁: 390
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