標題: Tandem One-Pot Acetalation-Acetylation for Direct Access to Differentially Protected Thioglycosides and O-Glycosides with p-Toluenesulfonic Acid
作者: Mong, Kwok-Kong Tony
Chao, Chin-Sheng
Chen, Min-Chun
Lin, Chun-Wei
應用化學系
Department of Applied Chemistry
關鍵字: tandem;acetals;glycosides;oligosaccharides;protecting group
公開日期: 3-三月-2009
摘要: A new tandem one-pot acetalation-acetylation procedure is reported which streamlines routine protecting-group manipulation of carbohydrate molecules in production of differentially protected 0- and thioglycosides. This new procedure eliminates the use of highly toxic pyridine, and p-toluenesulfonic acid is employed as catalyst for acetalation and acetylation. Synthetic utility of the new procedure is demonstrated in the expeditious preparation of differentially protected glycosides from a wide variety of carbohydrate substrates including unprotected O-glycosides, thioglycosides, and N-acetyl neuraminic acid ester.
URI: http://dx.doi.org/10.1055/s-0028-1087913
http://hdl.handle.net/11536/7506
ISSN: 0936-5214
DOI: 10.1055/s-0028-1087913
期刊: SYNLETT
Volume: 
Issue: 4
起始頁: 603
結束頁: 606
顯示於類別:期刊論文


文件中的檔案:

  1. 000264658300016.pdf