標題: A Phototransistor-Based High-Sensitivity Biosensing System Using 650-nm Light
作者: Chang, Yu-Wei
Tai, Yu-Ting
Huang, Yang-Tung
Yang, Yuh-Shyong
生物科技學系
電子工程學系及電子研究所
Department of Biological Science and Technology
Department of Electronics Engineering and Institute of Electronics
關鍵字: Biomedical transducers;medical diagnosis;photodetectors;phototransistors
公開日期: 1-五月-2009
摘要: A miniature optical biosensing system based on a PMOS phototransistor and absorption photometry is proposed. The phototransistor was manufactured in a standard 0.35-mu m CMOS process, and it exhibited a responsivity higher than 1000 A/W for 650-nm light. For biochemical applications, the TMB/H(2)O(2)/HRP method was adopted as a useful basis in our system. A sample volume of only 10 mu l was required to be dropped on the slide above the phototransistor. Experimental results demonstrated that a high sensitivity of 2.5 mu A/pM was achieved, and the minimum HRP concentration successfully detected was 2.7 pM. This detection limit is three orders of magnitude better than that of a lately reported silicon biosensor, and is even comparable to that of a commercial spectrophotometer.
URI: http://dx.doi.org/10.1109/JSEN.2009.2020675
http://hdl.handle.net/11536/7315
ISSN: 1530-437X
DOI: 10.1109/JSEN.2009.2020675
期刊: IEEE SENSORS JOURNAL
Volume: 9
Issue: 5-6
起始頁: 673
結束頁: 677
顯示於類別:期刊論文


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