標題: Design and fabrication of a polyimide-based microelectrode array: Application in neural recording and repeatable electrolytic lesion in rat brain
作者: Chen, You-Yin
Lai, Hsin-Yi
Lin, Sheng-Huang
Cho, Chien-Wen
Chao, Wen-Hung
Liao, Chia-Hsin
Tsang, Siny
Chen, Yi-Fan
Lin, Si-Yue
電控工程研究所
Institute of Electrical and Control Engineering
關鍵字: Microelectrode array;Polyimide;Electroplating;Chronic recording;Electrolytic lesion
公開日期: 30-Aug-2009
摘要: The design and testing of a new microelectrode array, the NCTU (National Chiao Tung University) probe, was presented. Evaluation results showed it has good biocompatibility, high signal-to-noise ratio (SNR: the root mean square of background noise to the average peak-to-peak amplitude of spikes) during chronic neural recordings, and high reusability for electrolytic lesions. The probe was a flexible, polyimide-based microelectrode array with a long shaft (14.9 mm in length) and 16 electrodes (5 mu m-thick and 16 mu m in radius); its performance in chronic in vivo recordings was examined in rodents. To improve the precision of implantation, a metallic, impact-resistant layer was sandwiched between the polyimide layers to strengthen the probe. The three-dimensional (3D) structure of electrodes fabricated by electroplating produced rough textures that increased the effective surface area. The in vitro impedance of electrodes on the NCTU probe was 2.4 +/- 0.52 M Omega at 1 kHz. In addition, post-surgical neural recordings of implanted NCTU probes were conducted for up to 40 days in awake, normally behaving rats. The electrodes on the NCTU probe functioned well and had a high SNR (range: 4-5) with reliable in vivo impedance (<0.7 M Omega). The electrodes were also robust enough to functionally record events, even after the anodal current (30 mu A, 10 s) was repeatedly applied for 60 times. With good biocompatibility, high and stable SNR for chronic recording, and high tolerance for electrolytic lesion, the NCTU probe would serve as a useful device in future neuroscience research. (C) 2009 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jneumeth.2009.05.010
http://hdl.handle.net/11536/6785
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2009.05.010
期刊: JOURNAL OF NEUROSCIENCE METHODS
Volume: 182
Issue: 1
起始頁: 6
結束頁: 16
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