標題: Rep1p negatively regulating MDR1 efflux pump involved in drug resistance in Candida albicans
作者: Chen, Chia-Geun
Yang, Yun-Liang
Tseng, Kuo-Yun
Shih, Hsin-I
Liou, Ci-Hong
Lin, Chih-Chao
Lo, Hsiu-Jung
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Efflux pump;Candida albicans;Drug resistance
公開日期: 1-Sep-2009
摘要: Overexpression of MDR1 efflux pump is a major mechanism contributing to drug resistance in Candida albicans, the most common human fungal pathogen. To elucidate the regulatory pathway of drug resistance, we have identified a negative regulator of MDR1 and named it Regulator of Efflux Pump 1 (REP1). Overexpression of REPI in Saccharomyces cerevisiae increased susceptibility to fluconazole. Furthermore, null mutations on REP1 decreased the susceptibility to antifungal drugs in C albicans resulting from increased expression of MDR1 mRNA. Hence, Rep1p is involved in drug resistance by negatively regulating MDR1 in C albicans. (c) 2009 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.fgb.2009.06.003
http://hdl.handle.net/11536/6714
ISSN: 1087-1845
DOI: 10.1016/j.fgb.2009.06.003
期刊: FUNGAL GENETICS AND BIOLOGY
Volume: 46
Issue: 9
起始頁: 714
結束頁: 720
Appears in Collections:Articles


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