標題: Biocomplementary Interaction Behavior in DNA-Like and RNA-Like Polymers
作者: Cheng, Chih-Chia
Yen, Ying-Chieh
Ye, Yun-Sheng
Chang, Feng-Chih
應用化學系
Department of Applied Chemistry
關鍵字: adenine;biomaterials blending biopolymers;self-assemble;supramolecular complexes;supramolecular structures;thymine;uracil
公開日期: 1-Dec-2009
摘要: A series of nucleobased polymers and copolymers were synthesized through atom transfer radical polymerization (ATRP). Biocomplementary DNA-and RNA-like supramolecular complexes are formed in dilute DMSO solution through nucleobase recognition. (1)H NMR titration studies of these complexes in CDCl(3) indicated that thymine-adenine (T-A) and uracil-adenine (U-A) complexes form rapidly on the NMR time scale with high association constants (up to 534 and 671 M(-1), respectively) and result in significant T(g) increase. WAXD and differential scanning calorimetry analyzes in the bulk state indicate the presence of highly physical crosslinked structures and provide further details into the nature of the self-assembly of these systems. Furthermore, this study is of discussion on the difference in the hydrogen bond strength between T-A and U-A base pairs within polymer systems, indicating that the strength of hydrogen bonds in RNA U-A pairs is stronger than that in DNA T-A base pairs. (C) 2009 Wiley Periodicals, Inc. J Polym. Sci Part A: Polym Chem 47:6388-6395, 2009
URI: http://dx.doi.org/10.1002/pola.23679
http://hdl.handle.net/11536/6343
ISSN: 0887-624X
DOI: 10.1002/pola.23679
期刊: JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
Volume: 47
Issue: 23
起始頁: 6388
結束頁: 6395
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