標題: microRNA: A Master Regulator of Cellular Processes for Bioengineering Systems
作者: Sun, Wei
Li, Yi-Shuan Julie
Huang, Hsien-Da
Shyy, John Y-J.
Chien, Shu
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: microRNA;gene regulation;bioinformatics;deep sequencing
公開日期: 2010
摘要: microRNAs (miRNAs) are small RNAs 18 to 24 nucleotides in length that serve the pivotal function of regulating gene expression. Instead of being translated into proteins, the mature single-stranded miRNA binds to messenger RNAs (mRNAs) to interfere with the translational process. It is estimated that whereas only 1% of the genomic transcripts in mammalian cells encode miRNA, nearly one-third of the encoded genes are regulated by miRNA. Various bioinformatics databases, tools, and algorithms have been developed to predict the sequences of miRNAs and their target genes. In combination with the in silico approaches in systems biology, experimental studies on miRNA provide a new bioengineering approach for understanding the mechanism of fine-tuning gene regulation. This review aims to provide state-of-the-art information on this important mechanism of gene regulation for researchers working in biomedical engineering and related fields. Particular emphases are placed on summarizing the current tools and strategies for miRNA study from a bioengineering perspective and the possible applications of miRNAs (such as antagomirs and miRNA sponges) in biomedical engineering research.
URI: http://hdl.handle.net/11536/6219
http://dx.doi.org/10.1146/annurev-bioeng-070909-105314
ISBN: 978-0-8243-3512-0
ISSN: 1523-9829
DOI: 10.1146/annurev-bioeng-070909-105314
期刊: ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 12
Volume: 12
起始頁: 1
結束頁: 27
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