標題: Anticancer and Antioxidant Activities of the Peptide Fraction from Algae Protein Waste
作者: Sheih, I-Chuan
Fang, Tony J.
Wu, Tung-Kung
Lin, Peng-Hsiang
生物科技學系
Department of Biological Science and Technology
關鍵字: Algae;peptide;Chlorella vulgaris;antiproliferative
公開日期: 27-一月-2010
摘要: Algae protein waste is a byproduct during production of algae essence from Chlorella vulgaris. There is no known report on the anticancer peptides derived from the microalgae protein waste. In this paper, the peptide fraction isolated from pepsin hydrolysate of algae protein waste had strong dose-dependent antiproliferation and induced a post-G1 cell cycle arrest in AGS cells; however, no cytotoxicity was observed in WI-38 lung fibroblasts cells in vitro. The peptide fraction also revealed much better antioxidant activity toward peroxyl radicals and LDL than those of Trolox. Among these peptides, a potent antiproliferative, antioxidant, and NO-production-inhibiting hendecapeptide was isolated, and its amino acid sequence was VECYGPNRPQF. These results demonstrate that inexpensive algae protein waste could be a new alternative to produce anticancer peptides.
URI: http://dx.doi.org/10.1021/jf903089m
http://hdl.handle.net/11536/5949
ISSN: 0021-8561
DOI: 10.1021/jf903089m
期刊: JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
Volume: 58
Issue: 2
起始頁: 1202
結束頁: 1207
顯示於類別:期刊論文


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  1. 000273671900071.pdf