標題: A potential role for Helicobacter pylori heat shock protein 60 in gastric tumorigenesis
作者: Lin, Chen-Si
He, Pei-Juin
Tsai, Nu-Man
Li, Chi-Han
Yang, Shang-Chih
Hsu, Wei-Tung
Wu, Ming-Shiang
Wu, Chang-Jer
Cheng, Tain-Lu
Liao, Kuang-Wen
生物科技學系
Department of Biological Science and Technology
關鍵字: Helicobacter pylori;Heat shock protein 60;Tumorigenesis
公開日期: 5-Feb-2010
摘要: Helicobacter pylon has been found to promote the malignant process leading to gastric cancer. Heat shock protein 60 of H. pylori (HpHSP60) was previously been identified as a potent immunogene. This Study investigates the role of HpHSP60 in gastric cancer carcinogenesis. The effect of HpHSP60 on cell proliferation, anti-death activity, angiogenesis and cell migration were explored. The results showed that HpHSP60 enhanced migration by gastric cancer cells and promoted tube formation by umbilical vein endothelial cells (HUVECs); however, HpHSP60 did not increase cell Proliferation nor was this protein able to rescue gastric cancer cells from death. Moreover, the results also indicated HpHSP60 had different effects on AGS gastric cancer cells or THP-1 monocytic cells in terms of their expression of pro-inflammatory cytokines, which are known to be important to cancer development. We propose that HpHSP60 may trigger the initiation of carcinogenesis by inducing pro-inflammatory cytokine release and by promoting angiogenesis and metastasis. Thus, this extracellular pathogen-derived HSP60 is potentially a vigorous virulence factor that can act as a carcinogen during gastric tumorigenesis. (C) 2010 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bbrc.2010.01.010
http://hdl.handle.net/11536/5849
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2010.01.010
期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume: 392
Issue: 2
起始頁: 183
結束頁: 189
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