標題: Concurrent sympathetic activation and vagal withdrawal in hyperthyroidism: Evidence from detrended fluctuation analysis of heart rate variability
作者: Chen, Jin-Long
Shiau, Yuo-Hsien
Tseng, Yin-Jiun
Chiu, Hung-Wen
Hsiao, Tzu-Chien
Wessel, Niels
Kurths, Juergen
Chu, Woei-Chyn
資訊工程學系
Department of Computer Science
關鍵字: Hyperthyroidism;Autonomic nervous system;Heart rate variability;Detrended fluctuation analysis;Nonlinear dynamics
公開日期: 1-五月-2010
摘要: Despite many previous Studies on the association between hyperthyroidism and the hyperadrenergic state, controversies still exist. Detrended fluctuation analysis (DFA) is a well recognized method in the nonlinear analysis of heart rate variability (HRV), and it has physiological significance related to the autonomic nervous system. In particular, an increased short-term scaling exponent alpha 1 calculated from DFA is associated with both increased sympathetic activity and decreased vagal activity. No study has investigated the DFA of HRV in hyperthyroidism. This study was designed to assess the sympathovagal balance in hyperthyroidism. We performed the DFA along with the linear analysis of HRV in 36 hyperthyroid Graves' disease patients (32 females and 4 males; age 30 +/- 1 years, means +/- SE) and 36 normal controls matched by sex, age and body mass index. Compared with the normal controls, the hyperthyroid patients revealed a significant increase (P < 0.001) in alpha 1 (hyperthyroid 1.28 +/- 0.04 versus control 0.91 +/- 0.02), long-term scaling exponent alpha 2 (1.05 +/- 0.02 versus 0.90 +/- 0.01), overall scaling exponent alpha (1.11 +/- 0.02 versus 0.89 +/- 0.01), low frequency power in normalized units (LF%) and the ratio of low frequency power to high frequency power (LF/HF); and a significant decrease (P < 0.001) in the standard deviation of the R-R intervals (SDNN) and high frequency power (HF). In conclusion, hyperthyroidism is characterized by concurrent sympathetic activation and vagal withdrawal. This sympathovagal imbalance state in hyperthyroidism helps to explain the higher prevalence of atrial fibrillation and exercise intolerance among hyperthyroid patients. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.physa.2009.12.062
http://hdl.handle.net/11536/5446
ISSN: 0378-4371
DOI: 10.1016/j.physa.2009.12.062
期刊: PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
Volume: 389
Issue: 9
起始頁: 1861
結束頁: 1868
顯示於類別:期刊論文


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