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dc.contributor.author鄭智綸en_US
dc.contributor.authorCheng, Chih-Lunen_US
dc.contributor.author林伯昰en_US
dc.contributor.authorLin, Bor-Shyhen_US
dc.date.accessioned2014-12-12T01:46:04Z-
dc.date.available2014-12-12T01:46:04Z-
dc.date.issued2010en_US
dc.identifier.urihttp://140.113.39.130/cdrfb3/record/nctu/#GT079805516en_US
dc.identifier.urihttp://hdl.handle.net/11536/46666-
dc.description.abstract在神經醫學當中,近紅外光譜術是一項全新的量測技術。他可以在非侵入式的量測之下得到含氧血紅素與缺氧血紅素的資訊,而這些資訊代表著我們腦中的血容量以及含氧的飽和度。因此近紅外光譜術非常有淺力用於非侵入式量測的方式,來觀察人腦因缺血缺氧引起的中風。但是在缺血缺氧中風方面,現今的研究仍缺乏有力的生理參數資訊。在此篇研究當中我們利用近紅外光譜術找出有意義的生理參數資訊。微透析裝置所量測到的L/P ratio在老鼠的中大腦動脈阻塞之下,也被用來與近紅外光譜術的含氧與缺氧血紅素做比較。在進行老鼠中大腦動脈阻塞的試驗之後,老鼠大腦會利用三苯基氯化染色來確認受損的情況。最後在缺血缺氧中風中,總和血紅素以及含氧與缺氧血紅素的差值也是重要的參數資訊。在實驗的結果當中,含氧與缺氧血紅素對於腦中風有明顯的生理意義,並且兩者的差值有更明顯的差別與生理意義。zh_TW
dc.description.abstractNear-infrared spectroscopy is a novel measuring technology in neuroscience. It can be used to non-invasively measure the relative concentrations of oxy-hemoglobin (HbO2) and deoxy- hemoglobin (HbR) which can reflect the information related to cerebral blood volume and cerebral oxygen saturation. Therefore, it has the potential for noninvasive monitoring of cerebra ischemia. However, it still lacks reliable physiological information in cerebra ischemia. In this study, we attempt to find meaningful information related to cerebra ischemia from the relative concentrations of HbO2 and HbR measured by near-infrared spectroscopy. The value of L/P ratio measured by using microdylasis is also used to compare with the concentration variation of HbR and HbO2 under middle cerebral artery occlusion. The rat brain slices with triphenyltetrazolium chloride stain is made to confirm the infract region of the rat brain caused by middle cerebral artery occlusion. Finally, total haemoglobin concentration and concentration difference between HbO2 and HbR for cerebra ischemia are also investigated. The experimental results show the concentration variation of HbR and HbO2 certainly can reflect the state of cerebra ischemia, and the concentration difference between HbO2 and HbR can provide meaningful information for monitoring cerebra ischemia.en_US
dc.language.isoen_USen_US
dc.subject中大腦動脈阻塞zh_TW
dc.subject含氧血紅素zh_TW
dc.subject微透析zh_TW
dc.subject缺氧血紅素zh_TW
dc.subject缺血缺氧中風zh_TW
dc.subject近紅外光譜術zh_TW
dc.subjectdeoxy-hemoglobinen_US
dc.subjectischemia strokeen_US
dc.subjectmicrodylasisen_US
dc.subjectmiddle cerebral occlusionen_US
dc.subjectnear-infrared spectroscopyen_US
dc.subjectoxy-hemoglobinen_US
dc.title應用於監測中大腦動脈阻塞之無線多通道近紅外光譜儀設計zh_TW
dc.titleDevelopment of wireless multi-channel near-infrared spectroscopy for monitoring middle cerebral artery occlusionen_US
dc.typeThesisen_US
dc.contributor.department照明與能源光電研究所zh_TW
Appears in Collections:Thesis