標題: Synthesis and Characterization of PEG-PCL-PEG Triblock Copolymers as Carriers of Doxorubicin for the Treatment of Breast Cancer
作者: Cuong, Nguyen-Van
Hsieh, Ming-Fa
Chen, Yung-Tsung
Liau, Ian
應用化學系分子科學碩博班
Institute of Molecular science
關鍵字: nanoparticles;micelles;drug delivery systems;multidrug resistance;monomethoxy poly(ethylene glycol);poly(epsilon-caprolactone)
公開日期: 15-Sep-2010
摘要: Triblock copolymers of monomethoxy poly(ethylene glycol) (mPEG) and epsilon-caprolactone (CL) were prepared with varying lengths of poly(E-caprolactone) (PCL) compositions and a fixed length of mPEG segment. The molecular characteristics of triblock copolymers were characterized by NMR, gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and differential scanning calorimetry (DSC). These amphiphilic linear copolymers based on PCL hydrophobic chain and hydrophilic mPEG ending, which can self-assemble into nanoscopic micelles with their hydrophobic cores, encapsulated doxorubicin (DOX) in an aqueous solution. The particle size of prepared micelles was around 40-92 nm. The DOX loading content and DOX loading efficiency were from 3.7-7.4% to 26-49%, respectively. DOX-released profile was pH-dependent and faster at pH 5.4 than pH 7.4. Additionally, the cytotoxicity of DOX-loaded micelles was found to be similar with free DOX in drug-resistant cells (MCF-7/adr). The great amounts of DOX and fast uptake accumulated into the MCF-7/adr cells from DOX-loaded micelles suggest a potential application in cancer chemotherapy. (C) 2010 Wiley Periodicals, Inc. J Appl Polym Sci 117: 3694-3703, 2010
URI: http://dx.doi.org/10.1002/app.32266
http://hdl.handle.net/11536/32188
ISSN: 0021-8995
DOI: 10.1002/app.32266
期刊: JOURNAL OF APPLIED POLYMER SCIENCE
Volume: 117
Issue: 6
起始頁: 3694
結束頁: 3703
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