標題: Differences in white matter abnormalities between bipolar I and II disorders
作者: Liu, Jia-Xiu
Chen, Yong-Sheng
Hsieh, Jen-Chuen
Su, Tung-Ping
Yeh, Tzu-Chen
Chen, Li-Fen
資訊工程學系
Department of Computer Science
關鍵字: Bipolar disorder;White matter;Diffusion tensor imaging;Voxel-wise analysis
公開日期: 1-Dec-2010
摘要: Background: Although patients with bipolar I and II disorders exhibit heterogeneous clinical presentations and cognitive functions, it remains unclear whether these two subtypes have distinct neural substrates. This study aimed to differentiate the fiber abnormalities between bipolar I and II patients using diffusion tensor images. Method: Fourteen bipolar I patients, thirteen bipolar II patients, and twenty-one healthy subjects were recruited. Fractional anisotropy (FA) values calculated from diffusion tensor images were compared among groups using two-sample t-test analysis in a voxel-wise manner. Correlations between the mean FA value of each survived area and the clinical characteristics as well as the scores of neuropsychological tests were further analyzed. Results: Patients of both subtypes manifested fiber impairments in the thalamus, anterior cingulate, and inferior frontal areas, whereas the bipolar II patients showed more fiber alterations in the temporal and inferior prefrontal regions. The FA values of the subgenual anterior cingulate cortices for both subtypes correlated with the performance of working memory. The FA values of the right inferior frontal area of bipolar land the left middle temporal area of bipolar II both correlated with executive function. For bipolar II patients, the left middle temporal and inferior prefrontal FA values correlated with the scores of YMRS and hypomanic episodes, respectively. Conclusions: Our findings suggest distinct neuropathological substrates between bipolar I and II subtypes. The fiber alterations observed in the bipolar I patients were majorly associated with cognitive dysfunction, whereas those in the bipolar II patients were related to both cognitive and emotional processing. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jad.2010.05.026
http://hdl.handle.net/11536/31903
ISSN: 0165-0327
DOI: 10.1016/j.jad.2010.05.026
期刊: JOURNAL OF AFFECTIVE DISORDERS
Volume: 127
Issue: 1-3
起始頁: 309
結束頁: 315
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