標題: Closed-loop seizure control on epileptic rat models
作者: Liang, Sheng-Fu
Liao, Yi-Cheng
Shaw, Fu-Zen
Chang, Da-Wei
Young, Chung-Ping
Chiueh, Herming
電機工程學系
Department of Electrical and Computer Engineering
公開日期: 1-Aug-2011
摘要: In this paper numerous alternative treatments in addition to pharmacological therapy are proposed for their use in epileptic patients. Epileptic animal models can play a crucial role in the performance evaluation of new therapeutic techniques. The objective of this research is to first develop various epileptic rat models; second, develop a portable wireless closed-loop seizure controller including on-line seizure detection and real-time electrical stimulation for seizure elimination; and third, apply the developed seizure controller to the animal models to perform on-line seizure elimination. The closed-loop seizure controller was applied to three Long-Evans rats with spontaneous spike-wave discharges (non-convulsive) and three Long-Evans rats with epileptiform activities induced by pentylenetetrazol (PTZ) injection (convulsive) for evaluation. The seizure detection accuracy is greater than 92% (up to 99%), and averaged seizure detection latency is less than 0.6 s for both spontaneous non-convulsive and PTZ-induced convulsive seizures. The average false stimulation rate is 3.1%. Near 30% of PTZ-induced convulsive seizures need more than two times of 0.5 s electrical stimulation for suppression and 90% of the non-convulsive seizures can be suppressed by only one 0.5 s electrical stimulation.
URI: http://dx.doi.org/10.1088/1741-2560/8/4/045001
http://hdl.handle.net/11536/29175
ISSN: 1741-2560
DOI: 10.1088/1741-2560/8/4/045001
期刊: JOURNAL OF NEURAL ENGINEERING
Volume: 8
Issue: 4
結束頁: 
Appears in Collections:Conferences Paper


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