標題: Hybridization sensing by electrical enhancement with nanoparticles in nanogap
作者: Chen, Chun-Chi
Ko, Fu-Hsiang
Chang, Edward Yi
Chang, Feng-Chih
Kuo, Shiao-Wei
材料科學與工程學系
材料科學與工程學系奈米科技碩博班
應用化學系
Department of Materials Science and Engineering
Graduate Program of Nanotechnology , Department of Materials Science and Engineering
Department of Applied Chemistry
關鍵字: bioelectric phenomena;biosensors;DNA;electric admittance;genetics;gold;monolayers;nanoparticles;nanotechnology
公開日期: 1-十一月-2008
摘要: In this work, the monolayer of gold nanoparticles within 72 nm gap has been proposed to function as a DNA sensor. The authors suggest that the nanoparticles in the nanogap could act as hopping sites which amplify the conductance of hybridized DNA strands. The conductance amplification between single strand and hybridized DNAs through gold nanoparticles is observed. Various concentrations of capture and target DNA are discussed for optimal hybridization sensing purpose. With the help of 1 nM capture DNAs, this sensor is able to analyze target DNA sequences at very low concentration of 1 fM. Furthermore, by means of adjusting the denature temperature to 60 degrees C, even single mismatch hybridization could be discriminated.
URI: http://dx.doi.org/10.1116/1.3002489
http://hdl.handle.net/11536/28754
ISSN: 1071-1023
DOI: 10.1116/1.3002489
期刊: JOURNAL OF VACUUM SCIENCE & TECHNOLOGY B
Volume: 26
Issue: 6
起始頁: 2572
結束頁: 2577
顯示於類別:會議論文


文件中的檔案:

  1. 000261385600140.pdf