標題: Computing motif correlations in proteins
作者: Horng, JT
Huang, HD
Wang, SH
Chen, MY
Huang, SL
Hwang, JK
生物科技學系
Department of Biological Science and Technology
關鍵字: protein;motif;structural genomics;data mining;database
公開日期: 1-Dec-2003
摘要: Protein motifs, which are specific regions and conserved regions, are found by comparing multiple protein sequences. These conserved regions in general play an important role in protein functions and protein folds, for example, for their binding properties or enzymatic activities. The aim here is to find the existence correlations of protein motifs. The knowledge of protein motif/domain sharing should be important in shedding new light on the biologic functions of proteins and offering a basis in analyzing the evolution in the human genome or other genomes. The protein sequences used here are obtained from the PIR-NREF database and the protein motifs are retrieved from the PROSITE database. We apply data mining approach to discover the occurrence correlations of motif in protein sequences. The correlation of motifs mined can be used in evolution analyses and protein structure prediction. We discuss the latter, i.e., protein structure prediction in this study. The correlations mined are stored and maintained in a database system. The database is now available at http://bioinfo.csie.ncu.edu.tw/ProMotif/. (C) 2003 Wiley Periodicals, Inc.
URI: http://dx.doi.org/10.1002/jcc.10332
http://hdl.handle.net/11536/27359
ISSN: 0192-8651
DOI: 10.1002/jcc.10332
期刊: JOURNAL OF COMPUTATIONAL CHEMISTRY
Volume: 24
Issue: 16
起始頁: 2032
結束頁: 2043
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