標題: Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells
作者: Yang, NS
Shyur, LF
Chen, CH
Wang, SY
Tzeng, CM
生物科技學系
Department of Biological Science and Technology
關鍵字: Anoectochilus formosanus;MCF-7 cancer cells;pharmacogenomic activities;metabolite profiling
公開日期: 1-Jan-2004
摘要: Metabolite profiling and DNA microarray analysis of global gene expression profiles were employed to characterize the bioactivities of the herbal extract of Anoectochilus formosanus (AF), a popular folk medicine with anticancer activity, in MCF-7 cancer cells. The pharmacogenomic activities of this plant extract as a crude phytocompound mixture were compared to those conferred by the single-compound drug, plumbagin. A similar level of complexity in transcriptional regulation at the genomic level was observed for both AF extract- and plumbagin-treated MCF-7 cells, as revealed by the number of up- or downregulated genes as well as by the specific but distinct patterns found in the gene-clustering analysis. This finding offers evidence to support the search for fractionated medicinal herb extracts or phytocompound mixtures, in addition to single-compound drugs, as defined therapeutic agents. Copyright (C) 2004 National Science Council, ROC and S. Karger AG, Basel.
URI: http://dx.doi.org/10.1159/000077111
http://hdl.handle.net/11536/27256
ISSN: 1021-7770
DOI: 10.1159/000077111
期刊: JOURNAL OF BIOMEDICAL SCIENCE
Volume: 11
Issue: 3
起始頁: 418
結束頁: 422
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