標題: Identifying transcriptional regulatory sites in the human genome using an integrated system
作者: Huang, HD
Horng, JT
Sun, YM
Tsou, AP
Huang, SL
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 1-Mar-2004
摘要: This work develops an integrated system which, after a set of genes are inputted, is able to predict transcriptional regulatory sites and to detect the co-occurrence of these regulatory sites. The system integrates several site detection methods such as known site matching, over-presented oligonucleotide detection and DNA motif discovery programs. User profiles and history pages enable users to trace the sequence analyses of these transcriptional regulatory sites. Two groups of co-regulated genes were used to test the proposed system. The results predicted by the proposed system consist of known site homologs and putative regulatory sites. By comparing these sites with previously published results, the proposed system is able to help biologists identify possible candidates for the regulatory sites from groups of co-regulated genes. The integrated system is now available at http://rgsminer. csie.ncu.edu.tw/.
URI: http://dx.doi.org/10.1093/nar/gkh345
http://hdl.handle.net/11536/26985
ISSN: 0305-1048
DOI: 10.1093/nar/gkh345
期刊: NUCLEIC ACIDS RESEARCH
Volume: 32
Issue: 6
起始頁: 1948
結束頁: 1956
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