標題: Molecularly imprinted TiO2-matrix-assisted laser desorption/ionization mass spectrometry for selectively detecting alpha-cyclodextrin
作者: Chen, CT
Chen, YC
應用化學系
Department of Applied Chemistry
公開日期: 1-Mar-2004
摘要: This study describes a new means to conduct molecular recognition-based analysis using mass spectrometry. Taking advantage of the unique characteristic of the absorption capacity of the TiO2 sol-gel material in the UV region, a TiO2 sol-gel-deposited thin film was employed as the sample substrate to assist in UV laser desorption/ionization of analytes. Sol-gels are polymeric materials that are easy to prepare and modify at low temperatures. Molecularly imprinted TiO2 sol-gels were generated for molecular recognition-based analysis. alpha-Cyclodextrin (CD) was selected as the template molecule and doped into TiO2 in a sol-gel reaction. The molecularly imprinted TiO2 Sol was spin-coated on a glass slide, and appropriate template cavities in the TiO2 sol-gel material were formed after the template molecules were removed. We demonstrate that this modified glass slide can be used to select alpha-CD from a sample solution containing equal amounts of alpha-, beta-, and gamma-CD (50 ppb each, 18 mL); alpha-CD was directly detected from the modified glass slide by matrix-assisted laser desorption/ionization mass spectrometry without the addition of extra matrix. This approach provides a new detection method for molecular recognition-based analysis.
URI: http://dx.doi.org/10.1021/ac034986h
http://hdl.handle.net/11536/26966
ISSN: 0003-2700
DOI: 10.1021/ac034986h
期刊: ANALYTICAL CHEMISTRY
Volume: 76
Issue: 5
起始頁: 1453
結束頁: 1457
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