Full metadata record
DC FieldValueLanguage
dc.contributor.authorLeu, GZen_US
dc.contributor.authorLin, TYen_US
dc.contributor.authorHsu, JTAen_US
dc.date.accessioned2014-12-08T15:39:10Z-
dc.date.available2014-12-08T15:39:10Z-
dc.date.issued2004-05-21en_US
dc.identifier.issn0006-291Xen_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbrc.2004.04.019en_US
dc.identifier.urihttp://hdl.handle.net/11536/26762-
dc.description.abstractHCV infection can lead to chronic infectious hepatitis disease with serious sequelae. Interferon-alpha, or its PEGylated form, plus ribavirin is the only treatment option to combat HCV. Alternative and more effective therapy is needed due to the severe side effects and unsatisfactory curing rate of the current therapy. In this study, we found that several polyunsaturated fatty acids (PUFAs) including arachidonic acid (AA), docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) are able to exert anti-HCV activities using an HCV subgenomic RNA replicon system. The EC50 (50% effective concentration to inhibit HCV replication) of AA was 4 muM that falls in the range of physiologically relevant concentration. At 100 muM, alpha-linolenic acid, gamma-linolenic, and linoleic acid only reduced HCV RNA levels slightly and saturated fatty acids including oleic acid, myristic acid, palmitic acid, and steric acid had no inhibitory activities toward HCV replication. When AA was combined with IFN-alpha, strong synergistic anti-HCV effect was observed as revealed by an isobologram analysis. It will be important to determine whether PUFAs can provide synergistic antiviral effects when given as food supplements during IFN-based anti-HCV therapy. Further elucidation of the exact anti-HCV mechanism caused by AA, DHA, and EPA may lead to the development of agents with potent activity against HCV or related viruses. (C) 2004 Elsevier Inc. All rights reserved.en_US
dc.language.isoen_USen_US
dc.subjectHCVen_US
dc.subjectrepliconen_US
dc.subjectpolyunsaturated fatty acids including arachidonic aciden_US
dc.subjecteicosapentaenoic aciden_US
dc.subjectdocosahexaenoic aciden_US
dc.titleAnti-HCV activities of selective polyunsaturated fatty acidsen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.bbrc.2004.04.019en_US
dc.identifier.journalBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONSen_US
dc.citation.volume318en_US
dc.citation.issue1en_US
dc.citation.spage275en_US
dc.citation.epage280en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000221254200041-
dc.citation.woscount38-
Appears in Collections:Articles


Files in This Item:

  1. 000221254200041.pdf