標題: Three-Dimensional Reconstruction of Brain-wide Wiring Networks in Drosophila at Single-Cell Resolution
作者: Chiang, Ann-Shyn
Lin, Chih-Yung
Chuang, Chao-Chun
Chang, Hsiu-Ming
Hsieh, Chang-Huain
Yeh, Chang-Wei
Shih, Chi-Tin
Wu, Jian-Jheng
Wang, Guo-Tzau
Chen, Yung-Chang
Wu, Cheng-Chi
Chen, Guan-Yu
Ching, Yu-Tai
Lee, Ping-Chang
Lin, Chih-Yang
Lin, Hui-Hao
Wu, Chia-Chou
Hsu, Hao-Wei
Huang, Yun-Ann
Chen, Jing-Yi
Chiang, Hsin-Jung
Lu, Chun-Fang
Ni, Ru-Fen
Yeh, Chao-Yuan
Hwang, Jenn-Kang
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
公開日期: 11-一月-2011
摘要: Background: Animal behavior is governed by the activity of interconnected brain circuits. Comprehensive brain wiring maps are thus needed in order to formulate hypotheses about information flow and also to guide genetic manipulations aimed at understanding how genes and circuits orchestrate complex behaviors. Results: To assemble this map, we deconstructed the adult Drosophila brain into approximately 16,000. single neurons and reconstructed them into a common standardized framework to produce a virtual fly brain. We have constructed a mesoscopic map and found that it consists of 41 local processing units (LPUs), six hubs, and 58 tracts covering the whole Drosophila brain. Despite individual local variation, the architecture of the Drosophila brain shows invariance for both the aggregation of local neurons (LNs) within specific LPUs and for the connectivity of projection neurons (PNs) between the same set of LPUs. An open-access image database, named FlyCircuit, has been constructed for online data archiving, mining, analysis, and three-dimensional visualization of all single neurons, brain-wide LPUs, their wiring diagrams, and neural tracts. Conclusion: We found that the Drosophila brain is assembled from families of multiple LPUs and their interconnections. This provides an essential first step in the analysis of information processing within and between neurons in a complete brain.
URI: http://dx.doi.org/10.1016/j.cub.2010.11.056
http://hdl.handle.net/11536/25892
ISSN: 0960-9822
DOI: 10.1016/j.cub.2010.11.056
期刊: CURRENT BIOLOGY
Volume: 21
Issue: 1
起始頁: 1
結束頁: 11
顯示於類別:期刊論文


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  1. 000286485200020.pdf