標題: Label free sub-picomole level DNA detection with Ag nanoparticle decorated Au nanotip arrays as surface enhanced Raman spectroscopy platform
作者: Lo, Hung-Chun
Hsiung, Hsin-I
Chattopadhyay, Surojit
Han, Hsieh-Cheng
Chen, Chia-Fu
Leu, Jih Perng
Chen, Kuei-Hsien
Chen, Li-Chyong
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Biosensor;Surface enhanced Raman spectroscopy;DNA;Surface plasmon;Nanostructure
公開日期: 15-一月-2011
摘要: Label free optical sensing of adenine and thymine oligonucleotides has been achieved at the sub-picomole level using self assembled silver nanoparticles (AgNPs) decorated gold nanotip (AuNT) arrays. The platform consisting of the AuNTs not only aids in efficient bio-immobilization, but also packs AgNPs in a three dimensional high surface area workspace, assisting in surface enhanced Raman scattering (SERS). The use of sub-10 nm AgNPs with optimum inter-particle distance ensures amplification of the chemically specific Raman signals of the adsorbed adenine, thymine, cytosine and guanine molecules in SERS experiments. High temporal stability of the Raman signals ensured reliable and repeatable DNA detection even after three weeks of ambient desk-top conservation. This facile architecture, being three dimensional and non-lithographic, differs from conventional SERS platforms. (C) 2010 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.bios.2010.10.022
http://hdl.handle.net/11536/25879
ISSN: 0956-5663
DOI: 10.1016/j.bios.2010.10.022
期刊: BIOSENSORS & BIOELECTRONICS
Volume: 26
Issue: 5
起始頁: 2413
結束頁: 2418
顯示於類別:期刊論文


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