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dc.contributor.authorThummanagoti, Sumanen_US
dc.contributor.authorChen, Chih-Hauen_US
dc.contributor.authorXu, Zhan-Huien_US
dc.contributor.authorSun, Chung-Mingen_US
dc.date.accessioned2014-12-08T15:37:29Z-
dc.date.available2014-12-08T15:37:29Z-
dc.date.issued2011-02-01en_US
dc.identifier.issn1381-1991en_US
dc.identifier.urihttp://dx.doi.org/10.1007/s11030-010-9244-7en_US
dc.identifier.urihttp://hdl.handle.net/11536/25786-
dc.description.abstractTraceless synthesis of 2-aminoimidazoquinoxalinones has been performed on soluble polymer support under open-vessel microwave dielectric heating. The reaction progression is monitored directly by the conventional proton NMR which indicated no release of the substrate from the support. Fmoc-deprotected amino acid polymer conjugates react with 1,5-difluoro-2,4-dinitro benzene to yield polymer bound dinitro fluoro amines, which are further substituted by various primary amines to yield PEG-immobilized dinitrodiamines. Simultaneous reduction of aromatic meta-dinitro group leads to the traceless release of 2-quinoxalinones, followed by N-hetero cyclization with various isothiocyanates in the presence of mercury(II)chloride to furnish 2-aminoimidazoquinolinone rings with three points of diversity at rapid pace.en_US
dc.language.isoen_USen_US
dc.subjectTraceless liquid-phase strategyen_US
dc.subjectTricyclicquinoxalinoneimidazoleen_US
dc.subjectOpen-vessel microwave irradiationen_US
dc.titleScaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiationen_US
dc.typeArticleen_US
dc.identifier.doi10.1007/s11030-010-9244-7en_US
dc.identifier.journalMOLECULAR DIVERSITYen_US
dc.citation.volume15en_US
dc.citation.issue1en_US
dc.citation.spage101en_US
dc.citation.epage107en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.identifier.wosnumberWOS:000288460200008-
dc.citation.woscount2-
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