標題: Scaffold-directed and traceless synthesis of tricyclic quinoxalinone imidazoles under microwave irradiation
作者: Thummanagoti, Suman
Chen, Chih-Hau
Xu, Zhan-Hui
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Traceless liquid-phase strategy;Tricyclicquinoxalinoneimidazole;Open-vessel microwave irradiation
公開日期: 1-二月-2011
摘要: Traceless synthesis of 2-aminoimidazoquinoxalinones has been performed on soluble polymer support under open-vessel microwave dielectric heating. The reaction progression is monitored directly by the conventional proton NMR which indicated no release of the substrate from the support. Fmoc-deprotected amino acid polymer conjugates react with 1,5-difluoro-2,4-dinitro benzene to yield polymer bound dinitro fluoro amines, which are further substituted by various primary amines to yield PEG-immobilized dinitrodiamines. Simultaneous reduction of aromatic meta-dinitro group leads to the traceless release of 2-quinoxalinones, followed by N-hetero cyclization with various isothiocyanates in the presence of mercury(II)chloride to furnish 2-aminoimidazoquinolinone rings with three points of diversity at rapid pace.
URI: http://dx.doi.org/10.1007/s11030-010-9244-7
http://hdl.handle.net/11536/25786
ISSN: 1381-1991
DOI: 10.1007/s11030-010-9244-7
期刊: MOLECULAR DIVERSITY
Volume: 15
Issue: 1
起始頁: 101
結束頁: 107
顯示於類別:期刊論文


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  1. 000288460200008.pdf