標題: A computational approach to discover differential cooperation of regulatory sites in functionally related genes in yeast genome
作者: Huang, HD
Horng, JT
Chang, CH
Tsou, TS
Hong, JY
Liu, BJ
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
關鍵字: regulatory site;transcription factor;yeast;data mining;promoter
公開日期: 1-Nov-2004
摘要: The availability of genome-wide gene expression data provides a unique set of genes from which to decipher the mechanisms underlying the common transcriptional response. A set of transcription factors which bind to target sites regulate the gene transcription cooperatively. This motivates us to discover the site associations of known transcription factor binding sites and certain repetitive elements. Those over-represented repetitive elements in the promoter regions of functionally related genes are predicted as putative regulatory elements. The study is to analyze how the differential site associations of the known regulatory sites and putative regulatory elements are distributed in the promoter regions of groups of functionally related genes. The functional-specific site associations are discovered by a statistical approach and the over-represented repetitive elements involving in the site associations are possible to be transcription factor binding sites. The site associations facilitate to predict functional-specific putative regulatory elements and to identify genes potentially co-regulated by the putative regulatory elements. Our proposed approach is applied to Saccharomyces cerevisiae and the promoter regions of yeast ORFs.
URI: http://hdl.handle.net/11536/25707
ISSN: 1016-2364
期刊: JOURNAL OF INFORMATION SCIENCE AND ENGINEERING
Volume: 20
Issue: 6
起始頁: 1141
結束頁: 1159
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