標題: Hyperhomocysteinemia in Patients with Polypoidal Choroidal Vasculopathy: A Case Control Study
作者: Cheng, Hui-Chen
Liu, Jorn-Hon
Lee, Shui-Mei
Lin, Po-Kang
生醫電子轉譯研究中心
Biomedical Electronics Translational Research Center
公開日期: 22-Oct-2014
摘要: Purpose: To determine whether elevated plasma homocysteine and serum high sensitivity C-reactive protein (hsCRP) levels, two established risk factors of vascular diseases, are associated with polypoidal choroidal vasculopathy (PCV). Design: Retrospective case-control study. Methods: One hundred and nineteen consecutive patients with PCV and 119 matched controls were enrolled in a tertiary hospital from September 2008 to June 2013. Plasma homocysteine and serum hsCRP levels were measured. Associations among plasma homocysteine, serum hsCRP levels and PCV were further evaluated using multivariable logistic regression analysis. Results: The median plasma homocysteine level was significantly higher in patients with PCV than in the controls (12.20 mu mol/L vs. 9.80 mu mol/ L, p<0.001). The median serum hsCRP level was slightly higher in the PCV group (0.16 mg/dl vs. 0.11 mg/dl in control group, p = 0.07). After multivariable logistic regression analysis, each 1 mmol/ L increase of plasma homocysteine was associated with a 1.5-fold increase in likelihood of having PCV (OR, 1.54; 95% confidence interval (CI), 1.33-1.79, p<0.001). Conclusions: Hyperhomocysteinemia was associated with PCV and might play a role in the pathogenesis of PCV.
URI: http://dx.doi.org/10.1371/journal.pone.0110818
http://hdl.handle.net/11536/25327
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0110818
期刊: PLOS ONE
Volume: 9
Issue: 10
起始頁: 0
結束頁: 0
Appears in Collections:Articles


Files in This Item:

  1. 2b76f8fbd9f55cbeff7e93e334e55e19.pdf

If it is a zip file, please download the file and unzip it, then open index.html in a browser to view the full text content.