標題: Gender-related effects of prefrontal cortex connectivity: a resting-state functional optical tomography study
作者: Chuang, Ching-Cheng
Sun, Chia-Wei
交大名義發表
分子醫學與生物工程研究所
光電工程學系
National Chiao Tung University
Institute of Molecular Medicine and Bioengineering
Department of Photonics
公開日期: 1-Aug-2014
摘要: The prefrontal cortex (PFC) is thought to play an important role in "higher" brain functions such as personality and emotion that may associated with several gender-related mental disorders. In this study, the gender effects of functional connectivity, cortical lateralization and significantly differences in the PFC were investigated by using resting-state functional optical tomography (fOT) measurement. A total of forty subjects including twenty healthy male and twenty healthy female adults were recruited for this study. In the results, the hemoglobin responses are higher in the male group. Additionally, male group exhibited the stronger connectivity in the PFC regions. In the result of lateralization, leftward dominant was observed in the male group but bilateral dominance in the female group. Finally, the 11 channels of the inferior PFC regions (corresponding to the region of Brodmann area 45) are significant different with spectrum analysis. Our findings suggest that the resting-state fOT method can provide high potential to apply to clinical neuroscience for several gender-related mental disorders diagnosis. (C)2014 Optical Society of America
URI: http://dx.doi.org/10.1364/BOE.5.002503
http://hdl.handle.net/11536/25224
ISSN: 2156-7085
DOI: 10.1364/BOE.5.002503
期刊: BIOMEDICAL OPTICS EXPRESS
Volume: 5
Issue: 8
起始頁: 2503
結束頁: 2516
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